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Novartis 4000 series imaging software
4000 Series Imaging Software, supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/4000+series+imaging+software/4000+series+imaging+software/pm25462259-416-5-12
Average 90 stars, based on 1 article reviews
4000 series imaging software - by Bioz Stars, 2026-09
90/100 stars

Images

Related Articles

Imaging:

Article Title: Imaging Mass Spectrometry Detection of Gangliosides Species in the Mouse Brain following Transient Focal Cerebral Ischemia and Long-Term Recovery
Article Snippet: .. The instrument was controlled via 4000 Series imaging software (Novartis, Mississauga, ON, Canada). .. Data analysis and visualization were done using TissueView (Novartis, Mississauga, ON, Canada).

Article Title: MALDI mass spectrometry imaging of 1-methyl-4-phenylpyridinium (MPP+) in mouse brain.
Article Snippet: Parkinson’s disease (PD) is the second most common neurodegenerative disorder affecting *1 % of the population older than 60 years.. The administration of the proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice is one of the most widely used approach to elucidate the mechanisms of cell death involved in PD.. Its toxicity is attributed to its active metabolite 1-methyl-4-phenylpyridinium (MPP).

Article Title: MALDI imaging and structural analysis of rat brain lipid negative ions with 9-aminoacridine matrix.
Article Snippet: Mass spectrometry imaging is of growing interest for chemical mapping of lipids at the surface of tissue sections.. Many efforts have been devoted to optimize matrix choice and deposition technique for positive ion mode analyses.. The identification of lipid species desorbed from tissue sections in the negative mode can be significantly improved by using 9-aminoacridine together with a robust deposition method, yielding a superior signal-to-noise ratio and thus a better contrast for the ion images in comparison to classical matrices such as α-cyano-4-hydroxycinnamic acid, 2,5dihydroxybenzoic acid, or 2,4,6-trihydroxyacetophenone.

Article Title: Neuroprotective effects of a brain permeant 6-aminoquinoxaline derivative in cell culture conditions that model the loss of dopaminergic neurons in Parkinson disease.
Article Snippet: Parkinson disease is a neurodegenerative disorder of aging, characterized by disabling motor symptoms resulting from the loss of midbrain dopaminergic neurons and the decrease of dopamine in the striatum.. Current therapies are directed at treating the symptoms but there is presently no cure for the disease.. In order to discover neuroprotective compounds with a therapeutical potential, our research team has established original and highly regioselective methods for the synthesis of 2,3-disubstituted 6aminoquinoxalines.

Article Title: MALDI imaging mass spectrometry of lipids by adding lithium salts to the matrix solution.
Article Snippet: Mass spectrometry imaging of lipids using MALDI–TOF/TOF mass spectrometers is of growing interest for chemical mapping of organic compounds at the surface of tissue sections.. Many efforts have been devoted to the best matrix choice and deposition technique.. Nevertheless, the identification of lipid species desorbed from tissue sections remains problematic.

Article Title: A New Safety Concern for Glaucoma Treatment Demonstrated by Mass Spectrometry Imaging of Benzalkonium Chloride Distribution in the Eye, an Experimental Study in Rabbits
Article Snippet: .. The images were recorded using 4000 Series Imaging software ( www.maldi-msi.org , M. Stoeckli, Novartis Pharma, Basel, Switzerland), processed using Tissue View software (AB Sciex, Les Ulis, France), and are presented in . .. Whole rabbit eye cryosections were fixed in 4% PFA for 15 mn at 4°C, washed in PBS with 1% BSA, permeabilized with 0.01%-diluted Triton X100® (Sigma Chemical Company, St Louis, MO, USA) for 5 min and incubated for 2 h at 4°C with mouse immunoglobulins directed against rabbit pan-leukocyte antigen CD45 (1∶50; CBL1412, Cymbus Biotechnology, Chandlers Ford, UK), rabbit MHC Class II Leukocyte Antigen RLA-DR (1∶100; RDR34, Beckman coulter, Miami, FL, USA) and vimentin (V9; 1/50, Dako, Glostrup, Denmark)in order to detect inflammatory cell infiltration: leukocytes, antigen-presenting cells and Müller cell activation, respectively.

Article Title: Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF-SIMS.
Article Snippet: Mass spectrometry imaging is becoming a more and more widely used method for chemical mapping of organic and inorganic compounds from various surfaces, especially tissue sections.. Two main different techniques are now available: matrix-assisted laser desorption/ionizaton, where the sample, preliminary coated by an organic matrix, is analyzed by a UV laser beam; and secondary ion mass spectrometry, for which the target is directly submitted to a focused ion beam.. Both techniques revealed excellent performances for lipid mapping of tissue surfaces.

Software:

Article Title: Imaging Mass Spectrometry Detection of Gangliosides Species in the Mouse Brain following Transient Focal Cerebral Ischemia and Long-Term Recovery
Article Snippet: .. The instrument was controlled via 4000 Series imaging software (Novartis, Mississauga, ON, Canada). .. Data analysis and visualization were done using TissueView (Novartis, Mississauga, ON, Canada).

Article Title: MALDI mass spectrometry imaging of 1-methyl-4-phenylpyridinium (MPP+) in mouse brain.
Article Snippet: Parkinson’s disease (PD) is the second most common neurodegenerative disorder affecting *1 % of the population older than 60 years.. The administration of the proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice is one of the most widely used approach to elucidate the mechanisms of cell death involved in PD.. Its toxicity is attributed to its active metabolite 1-methyl-4-phenylpyridinium (MPP).

Article Title: MALDI imaging and structural analysis of rat brain lipid negative ions with 9-aminoacridine matrix.
Article Snippet: Mass spectrometry imaging is of growing interest for chemical mapping of lipids at the surface of tissue sections.. Many efforts have been devoted to optimize matrix choice and deposition technique for positive ion mode analyses.. The identification of lipid species desorbed from tissue sections in the negative mode can be significantly improved by using 9-aminoacridine together with a robust deposition method, yielding a superior signal-to-noise ratio and thus a better contrast for the ion images in comparison to classical matrices such as α-cyano-4-hydroxycinnamic acid, 2,5dihydroxybenzoic acid, or 2,4,6-trihydroxyacetophenone.

Article Title: Neuroprotective effects of a brain permeant 6-aminoquinoxaline derivative in cell culture conditions that model the loss of dopaminergic neurons in Parkinson disease.
Article Snippet: Parkinson disease is a neurodegenerative disorder of aging, characterized by disabling motor symptoms resulting from the loss of midbrain dopaminergic neurons and the decrease of dopamine in the striatum.. Current therapies are directed at treating the symptoms but there is presently no cure for the disease.. In order to discover neuroprotective compounds with a therapeutical potential, our research team has established original and highly regioselective methods for the synthesis of 2,3-disubstituted 6aminoquinoxalines.

Article Title: MALDI imaging mass spectrometry of lipids by adding lithium salts to the matrix solution.
Article Snippet: Mass spectrometry imaging of lipids using MALDI–TOF/TOF mass spectrometers is of growing interest for chemical mapping of organic compounds at the surface of tissue sections.. Many efforts have been devoted to the best matrix choice and deposition technique.. Nevertheless, the identification of lipid species desorbed from tissue sections remains problematic.

Article Title: A New Safety Concern for Glaucoma Treatment Demonstrated by Mass Spectrometry Imaging of Benzalkonium Chloride Distribution in the Eye, an Experimental Study in Rabbits
Article Snippet: .. The images were recorded using 4000 Series Imaging software ( www.maldi-msi.org , M. Stoeckli, Novartis Pharma, Basel, Switzerland), processed using Tissue View software (AB Sciex, Les Ulis, France), and are presented in . .. Whole rabbit eye cryosections were fixed in 4% PFA for 15 mn at 4°C, washed in PBS with 1% BSA, permeabilized with 0.01%-diluted Triton X100® (Sigma Chemical Company, St Louis, MO, USA) for 5 min and incubated for 2 h at 4°C with mouse immunoglobulins directed against rabbit pan-leukocyte antigen CD45 (1∶50; CBL1412, Cymbus Biotechnology, Chandlers Ford, UK), rabbit MHC Class II Leukocyte Antigen RLA-DR (1∶100; RDR34, Beckman coulter, Miami, FL, USA) and vimentin (V9; 1/50, Dako, Glostrup, Denmark)in order to detect inflammatory cell infiltration: leukocytes, antigen-presenting cells and Müller cell activation, respectively.

Article Title: Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF-SIMS.
Article Snippet: Mass spectrometry imaging is becoming a more and more widely used method for chemical mapping of organic and inorganic compounds from various surfaces, especially tissue sections.. Two main different techniques are now available: matrix-assisted laser desorption/ionizaton, where the sample, preliminary coated by an organic matrix, is analyzed by a UV laser beam; and secondary ion mass spectrometry, for which the target is directly submitted to a focused ion beam.. Both techniques revealed excellent performances for lipid mapping of tissue surfaces.



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